Mast Cell Support Protocol From Ann Haiden, DO
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Mast Cell Mediators – More Than Just Histamine
Mast cells are an integral part of both innate and adaptive immune response and are early responders. The cytoplasm of the mast cell contains 50–200 large granules that store healthy inflammatory mediators such as histamine, tryptase, prostaglandins, leukotrienes, and cytokines. These mediators are responsible for many of the mast cell-mediated reactions.
Mast cells have IgE receptors, so can cause degranulation and mediator release, but things such as lipopolysaccharides, gliadin, gut microbiota, and stress can also stimulate mast cell receptors to trigger mediator release.
Mast cells are heavily present in tissues that act as host barriers, like the skin, the mucous membranes of the nasal and respiratory tracts and the intestinal lining. Mast cells are involved in various functions of the GI tract influencing secretions, permeability, blood flow, visceral sensation and motility. When mast cells are activated in the gut, mast cell mediators such as tryptase and chymase directly promote gut permeability.
There is now emerging research on mast cell involvement in the digestive tract. Mast cells that are physically near nerves in the intestinal tract have been correlated with the. Since it is now known that there is bidirectional communication between the GI tract and the nervous system, and that neurons can communicate with the immune cells (including mast cells and their mediators).
The avoidance of environmental toxins and triggers is obviously key to reducing mast cell activation, but the role of stress cannot be overstated. Stress and mood management are key.
Dr. Ann Haiden, DO, an internal medicine physician and functional medicine specialist, knows mast cell activation syndrome up close and personal. Dr. Haiden is now sharing her Mast Cell Support Protocol with the Wellevate community. Sign in to take a look at this latest protocol in the Wellevate Expert Protocol Library, or, if you’re new to Wellevate, set up an account to view this and dozens of other protocols from today’s leading integrative and functional medicine experts!
Ann Haiden, DO, earned her Doctor of Osteopathic Medicine from the Chicago College of Osteopathic Medicine, completing her residency in Internal Medicine at the Kaiser Permanente Hospital in San Francisco and becoming board certified. She practiced at Kaiser Permanente in Vallejo,CA for nine years in the Internal Medicine department and Spine Clinic. She is now in private practice offering an integrative and progressive, functional medicine approach.